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OERG News

Covidien
First Study about low-osmolar non-ionic contrast media


Objectives:
The differences regarding adverse reactions in different low-osmolar non-ionic contrast media have not been investigated previously. Thus, the aim of this study was to identify differences in the incidence of adverse reactions in five different low-osmolar non-ionic contrast media.

methods:
we prospectively recorded all adverse events associated with five different low-osmolar non-ionic contrast media used in 8,931 consecutive patients for CT. Patients were randomly assigned to five groups: iomeprol 300mgI/mg, iopamidol 300mgl/ml and iohexol 300 mg/ml, iopromide 300mgl/ml and ioversol 320mg/ml

results:
Adverse events were observed in 241 patients (82,7%). the incidence of acute adverse reactions was significantly higher in the following groups: (1) iomeprol (3,9%) and iopromide (3,5%) groups, (2) patients aged 59 years or less (4,5%) compared with those aged 60 years or over (1,9%), (3) the first period (3,5%) compared with the late period (2,3%), (4) those with a past history of adverse reactions to contrast media (11,2%), and (5) patients receiving contrast media for the first time (3,3%) compared with those who had received them it previously (2,0%).

Conclusion:
the incidence of acute adverse reactions may be reduced in younger patients by using iopamidol, iohexol and ioversol